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These highlights do not include all the information necessary to use Depakote properly and efficiently. See comprehensive prescribing info for Depakote.
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Allergic reaction: This drug can cause a intense allergic response (hypersensitivity). Phone your medical doctor When you have the subsequent signs and symptoms. If your indications are critical or existence-threatening, contact 911 or your neighborhood emergency products and services or check out the nearest crisis space. These indications can incorporate:
Having zidovudine with divalproex sodium may raise the levels of zidovudine in One's body. Your medical professional may possibly keep an eye on you far more closely for Unwanted effects.
two. Depakote may possibly damage your unborn child. If you take Depakote during pregnancy for virtually any professional medical affliction, your little one is at risk for severe delivery defects that have an impact on the brain and spinal cord (such as spina bifida or neural tube defects). These defects can start out in the 1st month, even before you know that you are Expecting.
Individuals coming into the randomized phase have been then introduced to their assigned goal dose, steadily tapered off their concomitant AED and followed for an interval providing 22 months. Lower than 50% with the people randomized, even so, finished the examine. In clients transformed to Depakote monotherapy, the mean complete valproate concentrations for the duration of monotherapy ended up seventy one and 123 mcg/mL during the low dose and higher dose groups, respectively. The next table provides the results for all sufferers randomized who experienced no less than a person post-randomization evaluation.
Don’t take this drug once more when you’ve at any time experienced an allergic reaction to it. Taking it once again may very well be lethal (cause death).
Plasma clearance and quantity of distribution totally free diazepam had been minimized by 25% and twenty%, respectively, while in the presence of valproate. The elimination 50 percent-life of diazepam remained unchanged on addition of valproate.
Valproate more info is for that reason contraindicated for prophylaxis of migraine head aches in pregnant Ladies As well as in Women of all ages of childbearing probable that are not employing successful contraception [see Contraindications (4)].
are allergic to divalproex sodium, valproic acid, sodium valproate, or any with the components in Depakote. Begin to see the stop of the Medication Guidebook for an entire list of substances in Depakote. Possess a genetic challenge referred to as a urea cycle ailment.
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Desk four lists treatment-emergent adverse reactions which were reported by ≥ 5% of individuals during the significant dose valproate team, and for which the incidence was better than inside the reduced dose team, in a very controlled trial of Depakote monotherapy treatment of intricate partial seizures.
Getting warfarin with divalproex sodium may possibly improve the levels of warfarin in Your system. Your medical professional may possibly keep an eye on your INR a lot more usually if you have to consider divalproex sodium along with warfarin.
Speak with your pharmacist or Make contact with your local garbage/recycling Office to understand acquire-back again packages with your Neighborhood. See the FDA's Safe Disposal of Medicines website () For more info If you don't have entry to a consider-back application.